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RNA replication of CVB3 3A mutants in the presence of enviroxime, GW5074, and PIK93. (A, B) HeLa cells were infected with wt or mutant CVB3-Rluc for 30 min. Immediately after infection, Guanidine HCl (GuaHCl), enviroxime, GW5074, or PIK93 were added to the cells (B). Cells were lysed at different time points after infection to determine the intracellular Renilla luciferase activity.
