Table 1.
Radiochemical parameters for [123I]5-IA in acutely depressed (aMDD) and recovered depressed (rMDD) subjects and their respective controls (C-aMDD, C-rMDD).
| Measure | Acutely Depressed (aMDD, N=8) | aMDD Controls (C-aMDD, N=8) | Recovered Depressed (rMDD, N=15) | rMDD Controls (C-rMDD, N=15) | Statistics |
|---|---|---|---|---|---|
| Total parent level, kBq/mL | 0.37 (0.07) | 0.34 (0.17) | 0.28 (0.10) | 0.38 (0.006) | F3,38=5.1, p=0.005 |
| Free parent level, kBq/mL | 0.13 (0.02) | 0.11 (0.06) | 0.13 (0.02) | 0.09 (0.03) | F3,38=5.5, p=0.003 |
| Free fraction level, kBq/mL.% | 34.1 (3.2) | 31.7 (3.4) | 35.4 (3.0) | 33.1 (4.8) | F3,38=1.1, p=0.4 |
| Total injected dose, MBq | 363.5 (10.3) | 326.3 (62.6) | 360.2 (36.0) | 344.2 (46.3) | F3,42=0.9, p=0.48 |
| Bolus dose, MBq | 157.7 (7.1) | 148.1 (26.6) | 157.4 (15.7) | 149.3 (20.7) | F3,42=0.8, p=0.49 |
| Infusion dose, MBq | 206 (5.5) | 190.2 (33.3) | 202.9 (20.4) | 194.9 (25.7) | F3,42=0.9, p=0.45 |
| Bolus to infusion ratio | 7.0 (0.02) | 7.0 (0.04) | 7.0 (0.03) | 7.0 (0.03) | F3,42=1.4, 0.26 |