Table 1.
Published studies investigating the relationship between height and/or birth-weight and osteosarcoma.
| Author/Year | Age Group | Study Period | Country | N* | Study Design | Population | Ht/BW Presentation | Outcome | |
|---|---|---|---|---|---|---|---|---|---|
| Ht | BW | ||||||||
| Fraumeni, 1967 [17] | 0–18 | 1945–1965 | USA | 85/202 | case-control | hospital | percentiles, scores | S | — |
| Scranton et al. 1975 [19] | 4–64 | 1951–1971 | USA | 54 | cohort | two hospitals | Ht, percentiles | S | — |
| Goodman et al. 1978 [25] | 6–25 | 1973–1976 | USA | 18 | cohort | hospital | percentiles | S | — |
| Broström et al. 1979 [26] | <25 | 1972–1974 | Sweden | 19/195 | case-control | registry | means, SDS | NS | — |
| Vassilopoulou-Sellin et al. 1985 | — | 1977–1983 | USA | 39 | cohort | hospital | percentiles | NS | — |
| Operskalski et al. 1987 [28] | <25 | 1972–1982 | USA | 60/94 | case-control | registry | percentiles | NS | — |
| Pui et al. 1987 [29] | <18 | 1962–1985 | USA | 150 | cohort | hospital | SDS | NS | — |
| Hartley et al. 1988 [33] | <15 | 1980–1983 | UK | 12/146 | case-control | multiple registries | medians | — | NS |
| Glasser et al. 1991 [30] | <15 | 1977–1985 | USA | 68 | cohort | hospital | SDS | NS | — |
| Gelberg et al. 1997 [20] | 3–24 | 1978–1988 | USA | 67 ht, 126 BW | case-control | registry | Ht percentiles, OR | S | NS |
| Buckley et al. 1998 [31] | <18 | 1982–1983 | USA | 152/152 | case-control | registry | means (Ht), OR (BW) | NS | NS |
| Cool et al. 1998 [32] | ≤15 | 1981–1994 | UK | 63 | cohort | hospital | percentiles | NS | — |
| Rytting et al. 2000 [21] | <11 | 1978–1995 | USA | 30 | cohort | hospital | percentiles | S | — |
| Ruza et al. 2003 [22] | ≤18 | 1984–2000 | Spain | 58 | cohort | hospital | means, SDS | S | — |
| Cotterill et al. 2004 [23] | 3–39 | 1978–1997 | UK | 364 | cohort | registry | SDS | S | — |
| Longhi et al. 2005 [24] | 2–60 | 1981–2001 | Italy | 962 | cohort | hospital | SDS | S§ | — |
| Troisi et al. 2006 [18] | <40 | 1994–2000 | USA | 158/141 | case-control | multiple hospitals | Ht percentiles, OR | NS | S |
| Schuz & Forman, 2007 [34] | ≤14 | 1992–1994 | Germany | 94†/2,024 | case-control | registry | means, OR | — | NS |
*
number of cases/controls; BW = birth-weight; Ht = height; OR = odds ratio; pct = percentile; SDS = standard deviation scores; NS = cases are not significantly different from the reference population; S = significant studies where cases were determined to be taller or had higher BW than the reference population;
†
all bone tumor cases;
§
significant association between taller than average stature in cases <18 years only (N = 555); —, no data available; Shaded rows are data we have acquired.