Table 5.

Analysis of height at diagnosis as an osteosarcoma risk factor by individual study and aggregate data compared to a simulated reference population.

Citation	Percentile of height	case n (%)	OR* (95% CI)
Scranton et al. 1975	≤50th	21 (48.8)	1 (ref)
	51–89th	16 (37.2)	0.94 (0.49–1.81)
	≥90th	6 (14.0)	1.45 (0.59–3.60)
Pui et al. 1987	≤50th	71 (42.3)	1 (ref)
	51–89th	72 (42.8)	1.25 (0.90–1.74)
	≥90th	25 (14.9)	1.76 (1.12–2.78)
Unpublished case data†	≤50th	69 (32.2)	1 (ref)
	51–89th	98 (45.8)	1.77 (1.30–2.41)
	≥90th	47 (22.0)	3.38 (2.34–4.90)
Ruza et al. 2003	≤50th	22 (37.9)	1 (ref)
	51–89th	28 (48.3)	1.56 (0.89–2.72)
	≥90th	8 (13.8)	1.90 (0.85–4.28)
Unpublished case data‡	≤50th	14 (21.9)	1 (ref)
	51–89th	33 (51.5)	2.82 (1.51–5.28)
	≥90th	17 (26.6)	6.42 (3.16–13.03)
Cotterill et al. 2004	≤50th	150 (41.2)	1 (ref)
	51–89th	146 (40.1)	1.12 (0.89–1.41)
	≥90th	68 (18.7)	2.45 (1.84–3.27)
Troisi et al. 2006	≤50th	59 (37.8)	1 (ref)
	51–89th	66 (42.3)	1.30 (0.91–1.84)
	≥90th	31 (19.9)	2.84 (1.83–4.38)
Aggregate data§	≤50th	406 (38.2)	1 (ref)
	51–89th	456 (42.9)	1.35 (1.18–1.54)
	≥90th	202 (18.9)	2.60 (2.19–3.07)

^*Odds ratio and 95% confidence intervals, adjusted for age and gender;

^†from St. Jude Children’s Research Hospital, TN, USA;

^‡from University Clinic of Navarra, Spain;

^§aggregate analyses were additionally adjusted for study.