Table 2. Correlation between the classifications based on three prognostic GES and RFS in GIST samples in the two tests sets, separately and pooled.
|
Test set no. 1 (
N
=86; time to RFS available)
|
Test set no. 2 (
N
=60; time to RFS not available)
|
Pooled test sets (
N
=146; all samples)
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Prognostic |
Relapse
|
P -value a |
Relapse
|
P -value a |
Relapse
|
P -value a | ||||||
| GES | No | Yes | Total | OR (95% CI) | No | Yes | Total | OR (95% CI) | No | Yes | Total | OR (95% CI) |
| GGI | ||||||||||||
| Low-risk | 62 | 4 | 66 | 5.83E−06 | 42 | 4 | 46 | 5.94E−09 | 104 | 8 | 112 | 3.70E−13 |
| High-risk | 9 | 11 | 20 | 17.9 (4.2–94.8) | 1 | 13 | 14 | 114.2 (12.5–5653.5) | 10 | 24 | 34 | 29.8 (10.0–100.2) |
| 16-Kinase | ||||||||||||
| Low-risk | 48 | 3 | 51 | 1.04E−03 | 33 | 1 | 34 | 4.75E−07 | 81 | 4 | 85 | 3.77E−09 |
| High-risk | 23 | 12 | 35 | 8.1 (1.9–49.3) | 10 | 16 | 26 | 48.75 (6.2–2246.3) | 33 | 28 | 61 | 16.8 (5.3–71.1) |
| CINSARC | ||||||||||||
| Low-risk | 45 | 3 | 48 | 3.34E−03 | 32 | 0 | 32 | 5.54E−08 | 77 | 3 | 80 | 2.30E−09 |
| High-risk | 26 | 12 | 38 | 6.8 (1.6–40.8) | 11 | 17 | 28 | INF (9.4–Inf) | 37 | 29 | 66 | 19.7 (5.6–107.7) |
Abbreviations: CI=confidence interval; CINSARC=complexity index in sarcomas; GES=gene expression signature; GGI=Genomic Grade Index; GIST=gastrointestinal stromal tumour; OR=odds ratio; RFS=relapse-free survival.
a
Fisher’s exact test P-value with OR and CI associated.