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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2012 Sep 18;264(3):351–360. doi: 10.1016/j.taap.2012.09.007

Figure 1.

Figure 1

Genetic deletion of CYP1A1 increases systolic and diastolic BP, and reduces HR. (A) 24 h mean systolic and diastolic BP, (B) 24 h mean HR, (C) Hourly systolic BP over a 24 h light/dark cycle, (D) Hourly diastolic BP over a 24 h light/dark cycle, (E) Activity over a 24 h light/dark cycle, and (F) Difference in MAP between nighttime and daytime, as measured by radiotelemetry. Data represent mean ± SEM. Data in A, B, and F were analyzed by Student’s t-test; *p < 0.05, and in C, D and E by two-way, repeated measures ANOVA, using post hoc Holm-Sidak comparisons; *p < 0.05 (n=7/genotype).