EPA- and DHA-mediated vasodilation is significantly attenuated in pressurized mesenteric resistance arterioles at 40 and 60 mmHg. (A) EPA-mediated relaxation at 40 mmHg, (B) DHA-mediated relaxation at 40 mmHg, (C) EPA-mediated relaxation at 60 mmHg, and (D) DHA-mediated relaxation at 60 mmHg. All relaxation experiments were subjected to U46619 preconstriction. Data represent mean ± SEM and were analyzed by two-way, repeated measures ANOVA, using post hoc Holm-Sidak comparisons; *p < 0.05, compared to wildtype (n=8–14/genotype).