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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Mol Oral Microbiol. 2012 Jul 5;27(6):449–457. doi: 10.1111/j.2041-1014.2012.00657.x

Figure 1. Preventive treatment with AMD3100 abrogates P. gingivalis-induced periodontal bone loss.

Figure 1

BALB/c mice (10–12 weeks of age) were administered AMD3100 (or PBS control) through osmotic minipumps which were implanted subcutaneously 24 hours prior to oral infection with P. gingivalis (or vehicle only; sham) as described in the Methods. The mice were euthanized six weeks after the last inoculation with P. gingivalis, and bone loss measurements were performed in defleshed maxillae. Data are means ± SD (n = 5 mice per group); negative values indicate bone loss in P. gingivalis-infected mice relative to sham-infected controls. **P < 0.01 compared to control and all other experimental groups. AMD, AMD3100; Pg, P. gingivalis.