Table 2.
The distribution of clinical and pathological parameters and the levels of miR-200c in blood
| Parameter | n | miR-200c mean (SEM) | p value | High miR-200c n (%) | p value |
|---|---|---|---|---|---|
|
Age (y) |
|
|
0.985 |
|
0.0895* |
| < 70 |
32 |
100.3 (14.1) |
|
17 (53.1%) |
|
| ≥70 |
20 |
112 (21.9) |
|
11 (55%) |
|
|
Gender |
|
|
0.692** |
|
1*** |
| Male |
42 |
107.3 (13.5) |
|
23 (54.8%) |
|
| Female |
10 |
94.2 (26.8) |
|
5 (50%) |
|
|
Location |
|
|
0.742** |
|
1*** |
| Proximal, upper third |
13 |
120.0 (31.1) |
|
7 (53.8%) |
|
| Distal |
36 |
98.5 (12.8) |
|
19 (52.8%) |
|
| Multicentric |
3 |
114.2 (58.3) |
|
2 (66.7%) |
|
|
Stage |
|
|
0.211 |
|
0.191* |
| I-III |
21 |
90.3 (17.4) |
|
9 (42.9%) |
|
| IV |
31 |
114.6 (16.3) |
|
19 (61.3%) |
|
|
pT |
|
|
0.683 |
|
0.693*** |
| pT1-T2 |
18 |
93.2 (31.6) |
|
13 (72.2%) |
|
| pT3-T4 |
16 |
95.9 (17.6) |
|
13 (81.3%) |
|
|
pN |
|
|
0.516 |
|
0.259*** |
| Node Negative |
9 |
67.4 (28.4) |
|
3 (33.3%) |
|
| Node Positive |
24 |
115.9 (18.6) |
|
14 (58.3%) |
|
|
Histological type |
|
|
0.179 |
|
0.246* |
| Intestinal |
28 |
86.5 (15.1) |
|
13 (46.4%) |
|
| Diffuse |
24 |
126.2 (18.5) |
|
15 (62.5%) |
|
|
ECOG |
|
|
0.263 |
|
0.481*** |
| 0-1 |
37 |
94.2 (15.5) |
|
20 (54.1%) |
|
| 2 |
10 |
147.1 (56.2) |
|
7 (70%) |
|
|
Residual disease (R) |
|
|
0.113 |
|
0.312* |
| R0 |
20 |
89.7 (18.2) |
|
9 (4%) |
|
| R1-2 |
32 |
120.4 (27.9) |
|
19 (59.4%) |
|
|
Number of Metastatic sites |
|
|
0.551** |
|
0.753*** |
| 0 |
23 |
95.4 (16.5) |
|
11 (47.8%) |
|
| 1 |
21 |
113.2 (21.1) |
|
12 (57.1%) |
|
|
≥2 |
8 |
109.8 (31.1) |
|
5 (62.5%) |
|
|
Grade |
|
|
0.405 |
|
0.146* |
| Low |
21 |
73.6 (20.9) |
|
8 (38.1%) |
|
| High |
27 |
116.9 (23.1) |
|
16 (59.3%) |
|
|
Vascular / Perineural Invasion |
|
|
0.914 |
|
0.705* |
| No |
11 |
103.3 (22.8) |
|
5 (45.5%) |
|
| Yes |
19 |
97.5 (22.8) |
|
10 (52.6%) |
|
|
Neutrophils (10-9/L) |
|
|
0.705 |
|
0.696* |
| ≤ 7.5 |
39 |
104.4 (13.1) |
|
22 (56.4%) |
|
| >7.5 | 12 | 114.9 (29.4) | 6 (50%) |
The miR-200c relative expression levels (REL) are shown in arbitrary units. The levels of miR-200c were considered high when the REL was above the mean. Residual disease (R) was categorised as R0 when no residual disease was present and as R1-2 when microscopic or macroscopic residual disease was found. Mann–Whitney test. * Pearson χ2. **Kruskal-Wallis test. *** Fisher's exact test.