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Akt signaling represses basal motility as well as TGFβ-induced migration in an isoform-independent manner. MCF10A cells expressing vehicle control (V), Akt1 (1), Akt2 (2) or Akt3 (3) were either untreated or stimulated with TGFβ for 3 days. The motility of the resultant cells was assessed either by migration assay at 12-hours (A and B) or wound healing assay 20-hours later (C).
