Figure 6. Necrotic cells release factors, which block cross-priming of antigen-specific CD8⁺ T cells in vivo. (A and B) Necrotic B78OVA cells (F/T) electroporated with p(dI-dC) were mixed with whole B78 necrotic cells (A), or with soluble/particulate fractions from B78 necrotic cells (B) and injected into mice. In vivo CTL was performed 7 d after boost. Pooled data of 3 (A) or 2 experiments (B) with 3 mice per group are shown. *p < 0.05 as compared with 3 × F/T group (Student’s t test).