Table 1. Analysis of in vivo antitumor synergy by the fractional product method.
| Fractional tumor volume (FTV)* relative to untreated controls | |||||
|---|---|---|---|---|---|
| CY Mo+AdIL-12 or CyMe+AdIL-12 combined treatment | |||||
| Days† | Cy Mo/Cy Me | AdIL-12(109 TCID50) | Expected‡ | Observed | R§ |
| 6 |
0.36/0.46 |
0.51 |
0.184/0.234 |
0.173/0.263 |
1.1/0.9 |
| 12 |
0.27/0.26 |
0.25 |
0.068/0.066 |
0.065/0.145 |
1.1/0.5 |
| 18 | 0.23/0.12 | 0.17 | 0.040/0.020 | 0.032/0.047 | 1.2/0.4 |
* FTV, (experimental mean tumor volume)/(control mean tumor volume). †After treatment onset. ‡Cy Mo/Cy Me mean FTV × (AdIL-12 mean FTV). §R = Expected FTV/Observed FTV for Cy Mo + AdIL-12/Cy Me + AdIL-12. Ratios > 1 indicate a synergistic effect, while ratios < 1 indicate a less-than-additive effect.