Figure 6. In Vivo Efficacy of OfVIII in Hemophilia A Mice.

Hemophilia A mice were injected with either 100 µl saline or 300 U/kg ofVIII in 100 µl sterile saline via tail vein injection (n = 8). After 15 min, bleeding challenge was induced via tail transaction at 2 mm diameter. Blood was collected in pre-weighed vials of 13 ml sterile saline at 37°C. Blood loss was calculated and displayed as mg/g body weight. Mean blood loss for saline and ofVIII treatments were 32.2±9.37 and 1.15±2.57 mg/g body weight, respectively (P<0.001; Mann-Whitney U test).