Figure 4. Galectin-3 overexpression protects MNA cells from apoptosis.
Effect of transient Gal-3 overexpression (inset) on bleomycin-induced apoptosis in IMR-5 (A), KCNR (B) and GILIN (C) cells shown as percentage of apoptotic nuclei and/or p85PARP positive cells. D, The same analysis was performed on three distinct LAN5 stable clones overexpressing Gal-3 compared to three control clones. Data are represented as averages (+/− standard deviations) of the raw data obtained (see Fig. S2). Significant differences in apoptosis fold induction were obtained between Gal-3 and CTR transfected cells (** p<0.01; *** p<0.0001).