Table 1. Frequencies of HLA-DRB1 alleles among MS patients and healthy controls.
| Chi-square test or Fisher’s exact probability test | Logistic regression analysis | |||||||||||
| Phenotype frequency | Non adjusted | Adjusted with DRB1*0901 | Adjusted with DRB1*0901/DRB1*0405 | |||||||||
| MS (n = 145) | HCs (n = 367) | |||||||||||
| DRB1*X | n (%) | n (%) | pcorr | OR | 95%CI | pcorr | OR | 95%CI | pcorr | OR | 95%CI | pcorr |
| 0101 | 15 (10.3) | 51 (13.9) | 1 | 0.715 | 0.388–1.317 | 1 | 0.584 | 0.315–1.084 | 1 | 0.686 | 0.365–1.290 | 1 |
| 0403 | 9 (6.2) | 18 (4.9) | 1 | 1.283 | 0.563–2.926 | 1 | 1.239 | 0.535–2.869 | 1 | 1.385 | 0.591–3.244 | 1 |
| 0405 | 65 (44.8) | 98 (26.7) | 0.0013 | 2.230 | 1.494–3.330 | 0.0016 | 1.939 | 1.288–2.920 | 0.0273 | NA | NA | NA |
| 0406 | 17 (11.7) | 23 (6.3) | 0.6876 | 1.986 | 1.028–3.839 | 1 | 1.712 | 0.878–3.337 | 1 | 1.917 | 0.9715–3.783 | 1 |
| 0802 | 14 (9.7) | 26 (7.1) | 1 | 1.402 | 0.710–2.767 | 1 | 1.231 | 0.618–2.452 | 1 | 1.448 | 0.717–2.923 | 1 |
| 0803 | 19 (13.0) | 58 (15.8) | 1 | 0.803 | 0.460–1.404 | 1 | 0.678 | 0.385–1.195 | 1 | 0.745 | 0.420–1.323 | 1 |
| 0901 | 14 (9.7) | 101 (27.5) | 0.0002 | 0.282 | 0.155–0.511 | 0.0006 | NA | NA | NA | NA | NA | NA |
| 1101 | 5 (3.5) | 16 (4.4) | 1 | 0.784 | 0.282–2.180 | 1 | 0.749 | 0.265–2.114 | 1 | 0.822 | 0.288–2.343 | 1 |
| 1201 | 12 (8.3) | 33 (9.0) | 1 | 0.913 | 0.458–1.822 | 1 | 0.783 | 0.389–1.573 | 1 | 0.922 | 0.453–1.877 | 1 |
| 1202 | 2 (1.4) | 13 (3.5) | 1 | 0.381 | 0.085–1.709 | 1 | 0.340 | 0.075–1.539 | 1 | 0.349 | 0.076–1.597 | 1 |
| 1302 | 8 (5.5) | 49 (13.4) | 0.1998 | 0.379 | 0.175–0.822 | 0.2516 | 0.336 | 0.154–0.733 | 0.110 | 0.387 | 0.176–0.852 | 0.3300 |
| 1403 | 7 (4.8) | 8 (2.2) | 1 | 2.276 | 0.810–6.396 | 1 | 1.961 | 0.690–1.264 | 1 | 2.016 | 0.700–5.812 | 1 |
| 1405 | 4 (2.8) | 14 (3.8) | 1 | 0.715 | 0.232–2.210 | 1 | 0.666 | 0.213–2.085 | 1 | 0.713 | 0.225–2.257 | 1 |
| 1406 | 4 (2.8) | 8 (2.2) | 1 | 1.273 | 0.377–4.295 | 1 | 1.206 | 0.350–4.152 | 1 | 1.365 | 0.391–4.762 | 1 |
| 1454 | 5 (3.5) | 19 (5.2) | 1 | 0.654 | 0.240–1.786 | 1 | 0.607 | 0.220–1.677 | 1 | 0.679 | 0.244–1.894 | 1 |
| 1501 | 38 (26.2) | 60 (16.4) | 0.1908 | 1.817 | 1.145–2.885 | 0.2034 | 1.627 | 1.016–2.603 | 0.767 | 1.802 | 1.113–2.916 | 0.2992 |
| 1502 | 21 (14.5) | 80 (21.8) | 1 | 0.608 | 0.360–1.027 | 1 | 0.615 | 0.361–1.048 | 1 | 0.706 | 0.409–1.217 | 1 |
| Xa | 13 (9.0) | 22 (6.0) | ||||||||||
puncorr was corrected by multiplying the value by 18 to calculate pcorr.
Xa includes all observed alleles at the HLA-DRB1 locus with frequencies of less than 1% in subjects; DRB1*0301, DRB1*0401, DRB1*0404, DRB1*0407, DRB1*0410, DRB1*0701, DRB1*1001, DRB1*1106, DRB1*1301, DRB1*1601 and DRB1*1602.
CI, confidence interval; HCs, healthy controls; MS, multiple sclerosis; NA, not applicable; OR, odds ratio; pcorr, corrected p value.