Table 2. Frequencies of HLA-DPB1 alleles among MS patients and healthy controls.
| Chi-square test or Fisher’s exact probability test | Logistic regression analysis | |||||||||||
| Phenotype frequency | non adjusted | Adjusted with DPB1*0301 | Adjusted with DPB1*0301/DPB1*0401 | |||||||||
| MS (n = 145) | HCs (n = 367) | |||||||||||
| DPB1*X | n (%) | n (%) | pcorr | OR | 95%CI | pcorr | OR | 95%CI | pcorr | OR | 95%CI | pcorr |
| 0201 | 58 (40.0) | 117 (31.9) | 0.8094 | 1.425 | 0.957–2.121 | 0.8161 | 1.495 | 0.996–2.242 | 0.5217 | 1.385 | 0.919–2.086 | 1 |
| 0202 | 8 (5.5) | 19 (5.2) | 1 | 1.070 | 0.457–2.501 | 1 | 1.096 | 0.451–2.533 | 1 | 0.965 | 0.407–2.290 | 1 |
| 0301 | 21 (14.5) | 16 (4.4) | 0.0007 | 3.715 | 1.879–7.347 | 0.0016 | NA | NA | NA | NA | NA | NA |
| 0401 | 5 (3.5) | 46 (12.5) | 0.0198 | 0.249 | 0.097–0.641 | 0.0392 | 0.257 | 0.099–0.666 | 0.0512 | NA | NA | NA |
| 0402 | 27 (18.6) | 64 (17.4) | 1 | 1.083 | 0.659–1.782 | 1 | 1.195 | 0.7217–1.979 | 1 | 1.146 | 0.689–1.905 | 1 |
| 0501 | 102 (70.3) | 240 (65.4) | 1 | 1.255 | 0.830–1.903 | 1 | 1.526 | 0.981–2.374 | 0.610 | 1.351 | 0.861–2.119 | 1 |
| 0901 | 23 (15.9) | 80 (21.8) | 1 | 0.676 | 0.406–1.126 | 1 | 0.715 | 0.427–1.197 | 1 | 0.706 | 0.420–1.187 | 1 |
| 1301 | 4 (2.8) | 19 (5.2) | 1 | 0.520 | 0.174–1.554 | 1 | 0.583 | 0.194–1.747 | 1 | 0.594 | 0.196–1.795 | 1 |
| 1401 | 4 (2.8) | 10 (2.7) | 1 | 1.013 | 0.313–3.282 | 1 | 0.905 | 0.270–3.036 | 1 | 0.877 | 0.259 | 1 |
| Xb | 4 (2.8) | 5 (1.4) | ||||||||||
puncorr was corrected by multiplying the value by 10 to calculate pcorr.
Xb includes all observed alleles at the HLA-DPB1 locus with frequencies of less than 1% in subjects; DPB1*0601, DPB1*1601, DPB1*1701, DPB1*1901, DPB1*2201 and DPB1*4101.
CI, confidence interval; HCs, healthy controls; MS, multiple sclerosis; NA, not applicable; OR, odds ratio; pcorr, corrected p value.