Table 3. Comparison of phenotype frequencies of HLA-DRB1 alleles between MS patients and healthy controls in individuals without the HLA-DRB1*0405 allele.
| MS (n = 80) | HCs (n = 269) | ||||
| DRB1*X | n (%) | n (%) | OR | 95%CI | pcorr |
| 0101 | 11 (13.8) | 46 (17.1) | 0.773 | 0.380–1.574 | 1 |
| 0403 | 5 (6.3) | 17 (6.3) | 0.988 | 0.353–2.768 | 1 |
| 0406 | 11 (13.8) | 20 (7.4) | 1.985 | 0.908–4.341 | 1 |
| 0802 | 10 (12.5) | 24 (8.9) | 1.458 | 0.666–3.194 | 1 |
| 0803 | 15 (18.8) | 45 (16.7) | 1.149 | 0.602–2.192 | 1 |
| 0901 | 10 (12.5) | 87 (32.3) | 0.299 | 0.147–0.608 | 0.0086 |
| 1101 | 4 (5.0) | 13 (4.8) | 1.036 | 0.328–3.271 | 1 |
| 1201 | 7 (8.8) | 32 (11.9) | 0.710 | 0.301–1.676 | 1 |
| 1202 | 2 (2.5) | 9 (3.4) | 0.741 | 0.157–3.500 | 1 |
| 1302 | 6 (7.5) | 44 (16.4) | 0.415 | 0.170–1.012 | 0.8007 |
| 1403 | 3 (3.8) | 7 (2.6) | 1.458 | 0.368–5.774 | 1 |
| 1405 | 4 (5.0) | 10 (3.7) | 1.363 | 0.416–4.469 | 1 |
| 1406 | 3 (3.8) | 7 (2.6) | 1.458 | 0.368–5.774 | 1 |
| 1454 | 3 (3.8) | 17 (6.3) | 0.578 | 0.165–2.023 | 1 |
| 1501 | 29 (36.3) | 45 (16.7) | 2.831 | 1.622–4.941 | 0.0030 |
| 1502 | 17 (21.3) | 70 (26.0) | 0.767 | 0.421–1.399 | 1 |
| Xe | 12 (15.0) | 20 (7.4) |
puncorr was corrected by multiplying the value by 17 to calculate pcorr.
Xe includes all observed alleles at the HLA-DRB1 locus with frequencies of less than 1% in subjects; DRB1*0301, DRB1*0401, DRB1*0404, DRB1*0407, DRB1*0410, DRB1*0701, DRB1*1001, DRB1*1106, DRB1*1301, DRB1*1601 and DRB1*1602.
CI, confidence interval; HCs, healthy controls; MS, multiple sclerosis; OR, odds ratio; pcorr, corrected p value.