Table 4. Comparison of demographic features and clinical characteristic of MS patients according to the presence or absence of the HLA-DRB1*0405 allele.
| 0405 (+) (n = 65) | 0405 (−) (n = 80) | puncorr | pcorr | |
| Male: female | 22 : 43 | 29 : 51 | 0.8615 | 1 |
| Age at onset (years)a | 27.22±10.45 | 34.84±13.76 | 0.0014 | 0.0126 |
| Disease duration (years)a | 12.83±9.68 | 10.22±7.27 | 0.1211 | 1 |
| EDSS scorea | 2.48±2.05 | 3.49±2.37 | 0.0078 | 0.0702 |
| Annualized relapse ratea | 0.54±0.45 | 0.70±0.78 | 0.2290 | 1 |
| Progression Indexa | 0.33±0.42 | 0.66±1.38 | 0.0017 | 0.0153 |
| OB/increased IgG indexb | 22/42 (52.4%) | 37/52 (71.2%) | 0.0859 | 1 |
| Barkhof criteriac | 31/58 (53.5%) | 51/70 (72.9%) | 0.0272 | 0.2448 |
| LESCLs | 3/58 (5.2%) | 5/71 (7.0%) | 0.7295 | 1 |
a
Values represent the mean ± SD.
b
CSF oligoclonal IgG bands (OB) and/or increased IgG index (upper normal limit = 0.658, according to our previous study [21].
c
Brain MRI lesions that meet the Barkhof criteria [29].
EDSS, Kurtzke’s Expanded Disability Status Scale; LESCLs, longitudinally extensive spinal cord lesions extending over three or more vertebral segments; MS, multiple sclerosis; OB, oligoclonal IgG bands.
puncorr was corrected by multiplying the value by nine to calculate pcorr.