Figure 3. SM-345431 enhances the corneal blink reflex.

The extension of nerve regeneration in the SM-345431 treated-group was significantly greater than control as measured by the total pixel count of traced axonal growth (A). In order to semi-quantitatively measure corneal sensation, a Cochet-Bonnet esthesiometer was used to measure the length of filament required to elicit a blink reflex. Three weeks postoperatively, the Sema3A inhibitor-treated group showed significant improvement in corneal sensitivity compared to the control group (B).