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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Pharmacol Biochem Behav. 2012 Aug 17;103(2):284–294. doi: 10.1016/j.pbb.2012.08.004

Figure 6.

Figure 6

Effects of indomethacin on ethanol withdrawal-related behavior in the social investigation test. Rats were injected with either 4-g/kg ethanol (EtOH; black squares) or saline (white circles). Fifteen hours later, animals were administered either a vehicle injection or 10 mg/kg indomethacin. 3 hr and 27 hr following this second injection (i.e. 18 and 42 hr after EtOH or saline exposure), animals were then tested in the social investigation test. Non-social pokes exhibited by (a) vehicle- and (c) indomethacin-exposed rats were analyzed, as well as pokes directed at the social hole by (b) vehicle- and (d) indomethacin-treated animals. Plus signs (+) indicate a significant difference between saline- and ethanol-exposed animals at a given testing time, collapsed across indomethacin treatment.