Fig. 4.

Effect of abstinence from meth on hypolocomotion in meth pre-exposed mice. Different groups of experimentally naïve, 8–10-week old female BALB/c mice (n=5/group) were intraperitoneally injected with varying doses of meth (day 0) and were then rested for a month. On day-30 different groups of mice were challenged intraperitoneally with a fixed dose of meth (0.01 mg/kg). Normalized baseline and other data were obtained as explained in Fig. 1. The arrow represents the time of meth injection. In the legend, left hand side values represent the dose of meth which was used for pre-exposure and the right hand side values represent the challenge dose. For example, 2.5/0.01 mg/kg means mice were exposed to 2.5 mg/kg meth, rested for a month and then challenged with 0.01 mg/kg meth. Data shown are mean ± S.E.M. Only some of the S.E.M. bars are shown for the clarity of the graphs. *P<0.001 for comparison vs. 0.01/0.01 mg/kg group.