Table 2. Median (interquartile range) binding globulin levels.
Group | Non-users | Inconsistent users | Compliant users | P* | P** | P*** |
---|---|---|---|---|---|---|
|
||||||
N | 12 | 9 | 42 | |||
| ||||||
CBG (mcg/mL) | ||||||
Baseline | 55.0 (50.0, 58.8) | 52.5 (40.0, 55.0) | 55.0 (47.5, 60.0) | 0.33 | 0.97 | 0.15 |
Follow-up | 58.8 (53.8, 68.8) | 90.0 (67.5, 102.5) | 107.5 (95.0, 120.0) | <0.001 | <0.001 | 0.004 |
Change | 1.3 (-3.8, 8.8) | 32.5 (17.5, 55.0) | 52.5 (40.0, 65.0) | <0.001 | <0.001 | 0.077 |
% change | 2.5 (-4.0, 15.5) | 57.0 (47.0, 137.0) | 92.5 (70.0, 138.0) | <0.001 | <0.001 | 0.29 |
| ||||||
TBG (mcg/mL) | ||||||
Baseline | 24.4 (21.7, 28.0) | 20.3 (18.3, 21.7) | 22.1 (19.2, 24.5) | 0.035 | 0.072 | 0.17 |
Follow-up | 25.6 (21.7, 30.5) | 21.5 (20.4, 23.3) | 31.7 (27.3, 38.4) | 0.001 | 0.015 | 0.002 |
Change | 1.5 (-1.2, 4.6) | 3.0 (0.6, 6.9) | 11.0 (7.7, 13.9) | <0.001 | <0.001 | 0.002 |
% change | 6.0 (-4.5, 16.3) | 15.1 (2.6, 34.0) | 51.1 (34.0, 64.4) | <0.001 | <0.001 | 0.005 |
| ||||||
SHBG (nmol/L) | ||||||
Baseline | 44.0 (32.2, 61.6) | 32.0 (27.9, 47.3) | 45.2 (37.4, 69.7) | 0.45 | 0.89 | 0.24 |
Follow-up | 48.1 (35.2, 79.4) | 60.5 (34.3, 74.1) | 80.1 (63.3, 97.4) | 0.009 | 0.022 | 0.012 |
Change | 3.7 (-6.3, 26.6) | 5.0 (-7.1, 27.2) | 30.1 (13.0, 40.9) | 0.045 | 0.034 | 0.088 |
% change | 8.4 (-10.6, 48.2) | 30.9 (-10.5, 104) | 70.1 (19.6, 104.5) | 0.01 | 0.003 | 0.22 |
Kruskal Wallis non-parametric analysis of variance (2 d.f.).
Nonusers versus compliant users.
Inconsistent users versus compliant users.