Table 2.
Associations between Plasma HIV-1 RNA and plasma cytokine levels
| Cytokine | Median (pg/mL) | IQR | % above LOD | Reg. Coef.+ | 95% CI | p-value# |
|---|---|---|---|---|---|---|
| IP-10* | 1459 | 836, 3265 | 100 | 0.73 | (0.047, 1.409) | 0.04 |
| IL-1α^ | 4.475 | 0.76, 14.1 | 58 | 0.52 | (−0.032, 1.070) | 0.06 |
| IL-17^ | 0.76 | 0.76, 0.76 | 10 | 0.80 | (−0.099, 1.688) | 0.08 |
| MCP-1* | 87.7 | 62.2, 136 | 100 | 0.59 | (−0.075, 1.255) | 0.08 |
| Eotaxin* | 21.2 | 15.9, 32.7 | 100 | 0.80 | (−0.158, 1.755) | 0.1 |
| GM-CSF* | 12.7 | 5.98, 49.0 | 94 | 0.34 | (−0.064, 0.754) | 0.1 |
| IL-6^ | 0.76 | 0.76, 0.76 | 17 | −0.61 | (−1.345, 0.126) | 0.1 |
| IL-12p70^ | 0.76 | 0.76, 1.18 | 25 | 0.49 | (−0.150, 1.121) | 0.1 |
| TNF-α* | 2.13 | 1.73, 3.15 | 90 | 0.50 | (−0.176, 1.176) | 0.1 |
| IFN-α2^ | 0.76 | 0.76, 2.31 | 25 | 0.45 | (−0.193, 1.083) | 0.2 |
| IFN-γ^ | 0.76 | 0.76, 1.75 | 27 | 0.40 | (−0.224, 1.024) | 0.2 |
| MIP-1α* | 25.8 | 12.0, 50.3 | 92 | 0.20 | (−0.112, 0.511) | 0.2 |
| IL-1β^ | 0.76 | 0.76, 0.76 | 10 | 0.450 | (−0.461, 1.367) | 0.3 |
| MIP-1β* | 31.0 | 14.2, 51.4 | 100 | 0.34 | (−0.285, 0.966) | 0.3 |
| IL-7^ | 0.76 | 0.76, 0.76 | 6 | 0.50 | (−0.657, 1.656) | 0.4 |
| IL-12p40^ | 0.76 | 0.76, 1.57 | 25 | 0.26 | (−0.388, 0.907) | 0.4 |
| G-CSF* | 8.84 | 5.95, 12.7 | 96 | 0.27 | (−0.536, 1.075) | 0.5 |
| IL-10^ | 0.76 | 0.76, 0.76 | 6 | 0.34 | (−0.826, 1.497) | 0.6 |
| IL-8* | 18.2 | 5.05, 43.3 | 94 | 0.06 | (−0.322, 0.446) | 0.7 |
+
Abbreviations: LOD: Limit of detection; Reg Coef: regression coefficient, CI: Confidence interval
*
log10 transformed values.
^
Dichotomized variable, testing for > lower limit
#
Nominal p-value is reported, with significant associations indicated by bold type based on p-value < 0.05. Those that remained significant after controlling for a false discovery rate of 5% are underlined, with the assumption of 26 tests.