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. Author manuscript; available in PMC: 2013 Nov 10.
Published in final edited form as: Circ Res. 2012 Sep 6;111(11):1398–1409. doi: 10.1161/CIRCRESAHA.112.269043

Figure 1. Myeloid cell-specific ABCA1 knockout (MSKO) mice are more resistant to Listeria Monocytogenes (Lm) infection.

Figure 1

Wild type (WT) and MSKO mice were i.p. infected with Lm (strain 10403S) for 3 days. (A) Body weight loss (left), and bacterial counts in liver (middle) and spleen (right) after 3 days of Lm infection. (B) Histological analysis of livers 3 days post Lm infection. Neutrophilic microabscesses are visualized by hematoxylin and eosin staining (objective magnification 10× and 40×) and immunohistochemical staining using an antibody against Ly6B.2 (neutrophil marker, objective magnification 40×). (C–D) Lipid analysis of livers 3 days post Lm infection. Hemtoxylin and eosin staining (objective magnification 40×) revealed massive accumulation of hepatic lipid droplets in Lm-infected WT mice relative to MSKO mice (C). Liver triglyceride (TG), free cholesterol (FC), and total cholesterol (TC) were measured by enzymatic assays (D). Data are expressed as mean ± SD. * P<0.05 and values with different letters are statistically different (P<0.05).