Table 2.
Pharmacokinetic Parameters for Lexatumumab by Dose Level
| Dose Level (mg/kg) | No. | Cmax (μg/mL) |
AUC0-last (μg × h/mL) |
AUC0-∞ (μg × h/mL) |
Percent Extrapolated |
t1/2 (days) |
CL (mL/d/kg) |
Vdss (mL/kg) |
Cmin (μg/mL) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | Coefficient of Variation (%) | Mean | Coefficient of Variation (%) | Mean | Coefficient of Variation (%) | Mean | Coefficient of Variation (%) | Mean | Coefficient of Variation (%) | Mean | Coefficient of Variation (%) | Mean | Coefficient of Variation (%) | Mean | Coefficient of Variation (%) | ||
| 3 | 3 | 46 | 37 | 4,695 | 64 | 7,063 | 87 | 21 | 99 | 6.8 | 70 | 20 | 92 | 93.7 | 3.3 | 6 | 108 |
| 5 | 3 | 99 | 21 | 13,757 | 8 | 21,835 | 7 | 37 | 15 | 9.9 | 13 | 17 | 116 | 79.7 | 12 | 24 | 12 |
| 8 | 6 | 155 | 26 | 19,872 | 24 | 28,969 | 22 | 32 | 20 | 8.5 | 16 | 6.9 | 20 | 74.4 | 48 | 31 | 23 |
| 10 | 9 | 193 | 29 | 26,499 | 27 | 37,886 | 27 | 30 | 31 | 7.9 | 37 | 6.8 | 29 | 72.5 | 34 | 42 | 19 |
Abbreviations: AUC, area under the serum concentration-time curve; Cmax, peak serum concentration; Cmin, trough serum concentration before second dose; CL, clearance; t1/2, half-life; Vdss, volume of distribution at steady state.