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. 2012 Nov 12;199(4):639–651. doi: 10.1083/jcb.201111042

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© 2012 Sivadas et al.

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Figure 1. — Predicted locations of RSP3 AKAP and the D/D domain–containing RSPs in the RS complex. RS is positioned between the microtubule outer doublet (left) and the CP (right). RSP3 dimer (orange circles) is thought to be the base of the RS. The RIIa domain–containing RSP7 and RSP11 are located toward the base, whereas the Dpy-30 domain–containing RSP2 and RSP23 are near the neck region underneath the spoke head. The prediction is based on RS deficiencies in RS mutants. Only a fraction of the 9 + 2 axoneme is depicted. The crystal structures of the RIIa and Dpy-30 domains were generated using PyMol (PDB accession numbers 1L6E [Morikis et al., 2002] and 3G36 [Wang et al., 2009]).