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. 2012 Nov 12;199(4):589–598. doi: 10.1083/jcb.201203150

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© 2012 Li et al.

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Figure 3. — ARL-13 SUMOylation is required for the proper ciliary targeting of sensory receptors and downstream sensory functions. (A) PKD-2 mislocalization in arl-13 can be rescued by the expression of wild-type ARL-13 but not ARL-13^K239,328R variant. Bar, 10 µm. (B) ARL-13^K239,328R fails to rescue the mating behavior defects of arl-13 animals. (C) ODR-10 mislocalization in fan-shape AWA cilia in arl-13 can be rescued by the expression of wild-type ARL-13 but not the ARL-13^K239,328R variant. Asterisks indicate the base of AWA cilia. Note the strong accumulation of ODR-10 in dendrites in arl-13 and ARL-13^K239,328R/arl-13 worms. Bar, 5 µm. (D) ARL-13^K239,328R fails to rescue the chemotaxis defects of arl-13 animals. For each line, experiments were done five times to obtain statistical data. The data were analyzed using an unpaired Student’s t test and are presented as mean ± SEM (error bars); *, P < 0.01. n.s., not significant.