Figure 5.
Genetic disruption of mGluR5 in the right amygdala reduces bladder distention-induced ERK phosphorylation. A, Representative Western blot showing phosphorylated ERK1 and ERK2 bands (top) and total ERK1 and ERK2 (bottom) from spinal cord tissue from LV-Cre-injected control mice (n = 9) or mGluR5CeAKO mice (n = 7) following graded bladder distention. B, Quantification of Western blots showing decreased ERK1 and ERK2 phosphorylation in mGluR5CeAKO mice compared with control mice (*p < 0.05, unpaired Student's t test compared with control group). Error bars indicate SEM.