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. 2012 Oct 3;109(45):18419–18424. doi: 10.1073/pnas.1213438109

Fig. 1.

Fig. 1.

Human Cdc20 has a preformed KEN-box-binding site at the top face of its WD40 β propeller. (A) Domains and motifs of human Cdc20. MIM, Mad2 Interacting Motif. (B) Ribbon diagram of human Cdc20. The N and C termini and the seven blades of the WD40 β propeller are labeled. The DYY insert in the loop connecting blades 1 and 7 is colored salmon. All structure figures in this report are generated with PyMOL (www.pymol.org). (C) Ribbon diagram of Wdr5 (PDB ID code 2GNQ). (D) Surface drawing of the Cdc20ΔN70–BubR1 KEN1 complex with BubR1 KEN1 shown as sticks. The DYY insert is colored salmon. (E) Surface drawing of the Wdr5–histone H3 complex (PDB ID code 2H9O), with the bound H3 peptide shown as sticks. (F) A cross-sectional view of the surface drawing of Cdc20–BubR1 KEN1 in D. (G) A cross-sectional view of the surface drawing of Wdr5–H3 in E.