Table 4.
Coefficients, standard errors, and p-values from the best models in each cohort for FTO rs9939609 predicting BMI profiles in non-Hispanic whites. There were no statistically significant interaction terms in the best model for the Project HeartBeat! cohort.
| Bogalusa Heart Study | Project HeartBeat! | |||||
|---|---|---|---|---|---|---|
| Effect | Coefficient | S.E. | p-value | Coefficient | S.E. | p-value |
| Intercept | 16.297 | 0.189 | <0.001 | 16.378 | 0.254 | <0.001 |
| Sex (0=F; 1=M) | -0.051 | 0.282 | 0.857 | 0.275 | 0.312 | 0.378 |
| Age (years)1 | 0.349 | 0.117 | 0.003 | 0.449 | 0.076 | <0.001 |
| Age squared | 0.101 | 0.027 | <0.001 | 0.111 | 0.018 | <0.001 |
| Age cubed | -0.008 | 0.002 | <0.001 | -0.010 | 0.001 | <0.001 |
| FTO (0=T/?; 1=A/A) | 0.668 | 0.289 | 0.021 | 1.155 | 0.431 | 0.008 |
| Age × FTO | 0.102 | 0.040 | 0.010 | – – – | – – – | – – – |
| Sex × Age | 0.353 | 0.178 | 0.048 | – – – | – – – | – – – |
| Sex × Age squared | -0.090 | 0.041 | 0.029 | – – – | – – – | – – – |
| Sex × Age cubed | 0.007 | 0.003 | 0.009 | – – – | – – – | – – – |
1
Age in each cohort was centered by subtracting the youngest age value from the Project HeartBeat! cohort (8.104 years) from each age value prior to squaring or cubing it.