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. Author manuscript; available in PMC: 2012 Nov 10.
Published in final edited form as: Chembiochem. 2011 Jun 28;12(12):1849–1853. doi: 10.1002/cbic.201100215

Figure 1.

Figure 1

A) Incorporation of FAS II intermediates (acyl-ACPs) into secondary metabolites and cofactors: N-dodecanoyl-phenylalanine (1), N-octanoyl homoserine lactone (2), enzyme-bound lipoic acid (3), and calcium-dependent antibiotic (CDA) (4). B) The domain architecture of nasB includes all three Pfam homology domains found in the E1α/E1β subuntis of 2-oxo acid dehydrogenase complexes, as well as both of the Pfam homology domains found in the E. coli FabH protein (β-ketoacyl-ACP synthase III). Separating these two sets of domains is an E2-like (E2*) lipoyl-attachment site.