Figure 4 .

A hypothetical model of how SPRR2A changes p53 acetylation and target gene transcription. Acetylated p53 has a greater binding affinity to specific RE in the DNA, promoting target gene transcription. Upper diagram: Vector cells have lower HDAC1 deacetylase activity, allowing acetylated p300 and other modulatory proteins to enhance K-382-p53 acetylation. Lower diagram: Enhanced HDAC1 expression in SPRR2A cells directly deacetylates p53 and competitively inhibits acetylation through p300/p53 interactions. In addition, SPRR2A expression reduces p300 acetylation, most likely through its effects on other proteins involved with p300 auto-acetylation.