Table 1.
Baseline characteristics stratified by HCV genotype
| HCV genotype 2 n = 103 | HCV genotype 3 n = 256 | P value | |
|---|---|---|---|
|
Male gender, n (%) |
62 (60) |
154 (60) |
0.920 |
|
Age, years |
49 (41–54) |
40 (32–48) |
<0.001 |
|
BMI, kg/m
2
|
25a (23–27) |
25b (23–28) |
0.290 |
|
ALT, U/l |
74a (44–144) |
108a (66–175) |
<0.001 |
|
Total cholesterol, mmol/L |
4.6c (4.1-5.4) |
3.9d (3.3-4.6) |
<0.001 |
|
Triglycerides, mmol/L |
0.9c (0.7-1.3) |
0.9d (0.7-1.4) |
0.748 |
|
Glucose, mmol/L |
4.9d (4.6-5.4) |
4.9e (4.5-5.4) |
0.507 |
|
Insulin, mIU/L |
12f (6–24) |
12e (7–26) |
0.458 |
|
HOMA-IR, U |
2.5g (1.3-6.0) |
2.7h (1.6-5.9) |
0.088 |
|
Baseline HCV RNA, log
10
IU/mL |
6.5 (5.8-6.8) |
6.1 (5.4-6.7) |
0.025 |
|
Steatosis
1
, n (%) |
49c (50) |
171i (73) |
<0.001 |
|
Cirrhosis
2
, n (%) |
14c (14) |
29i (12) |
0.807 |
| Diabetes mellitus, n (%) | 4d (4) | 7e (3) | 0.823 |
Categorical traits, expressed as number (n) and relative proportion (%), have been compared by χ2 test. Continuous traits are expressed as median (interquartile range) and have been analyzed using a linear regression model. For additional information on statistical analyses, see methods.
1Steatosis was defined as histological grade > 0. 2Cirrhosis was defined as Ishak stage 5–6.
Missing data: an = 1, bn = 8, cn = 4, dn = 6, en = 15, fn = 7, gn = 13, hn = 27,in = 23.
Abbreviations: HCV, hepatitis C virus; BMI, body mass index; ALT, alanine transferase; HOMA-IR, homeostasis model assessment for insulin resistance; II, individuals with two 148I alleles; MM, individuals with two 148 M alleles; IM, heterozygotes.