Table 3.
Baseline characteristics according to PNPLA3 I148M sequence variant in HCV genotype 3 patients
|
II |
IM |
MM |
P value |
P value |
|
|---|---|---|---|---|---|
| n = 159 | n = 91 | n = 6 | additive | recessive | |
|
Male gender, n (%) |
97 (61) |
52 (57) |
5 (83) |
0.466 |
0.407 |
|
Age, years |
39 (31–47) |
41 (35–48) |
42 (29–46) |
0.128 |
0.653 |
|
BMI, kg/m
2
|
26a (23–29) |
25a (23–28) |
26 (22–28) |
0.232 |
0.644 |
|
ALT, U/l |
108 (68–175) |
106d (62–181) |
69 (61–109) |
0.398 |
0.248 |
|
Total cholesterol, mmol/L |
4.0e (3.3-4.7) |
3.8a (3.2-4.5) |
3.7 (3.1-5.7) |
0.909 |
0.452 |
|
Triglycerides, mmol/L |
0.9e (0.7-1.3) |
0.9a (0.7-1.4) |
0.8 (0.6-1.1) |
0.336 |
0.256 |
|
Glucose, mmol/L |
4.9c (4.5-5.6) |
4.9f (4.6-5.3) |
4.8 (4.6-5.4) |
0.147 |
0.882 |
|
Insulin, mIU/L |
13g (7–26) |
12h (7–25) |
12 (6–39) |
0.800 |
0.785 |
|
HOMA-IR, U |
2.7i (1.5-6.1) |
2.6j (1.6-4.7) |
2.5 (1.5-8.4) |
0.882 |
0.941 |
|
Baseline HCV RNA, log
10
IU/mL |
6.0 (5.3-6.7) |
6.2 (5.6-6.7) |
6.8 (6.1-7.1) |
0.030 |
0.100 |
|
Steatosis
1
, n (%) |
99k (68) |
68c (82) |
4d (80) |
0.068 |
0.989 |
|
Cirrhosis
3
, n (%) |
17k (12) |
11c (13) |
1d (20) |
0.636 |
0.489 |
| Diabetes mellitus, n (%) | 6c (4) | 1f (1) | 0 (0) | 0.520 | 0.996 |
Categorical traits, expressed as number (n) and relative proportion (%), have been compared by Fisher exact test. Continuous traits are expressed as median (interquartile range) and have been analyzed using a linear regression model. For additional information on statistical analyses, see methods.
1Steatosis was defined as histological grade > 0. 2Cirrhosis was defined as Ishak stage 5–6.
Missing data: an = 4, bn = 18, cn = 8, dn = 1, en = 2, fn = 7, gn = 9, hn = 6, in = 16, jn = 11, kn = 14. Abbreviations: PNPLA3, patatin-like phospholipase domain-containing 3; HCV, hepatitis C virus; BMI, body mass index; ALT, alanine transferase; HOMA-IR, homeostasis model assessment for insulin resistance; II, individuals with two 148I alleles; MM, individuals with two 148 M alleles; IM, heterozygotes.