Table 1.
List of known and potential mammalian epoxide hydrolases.
| enzyme name | gene name | year first reported |
sub-cellular localization |
natural epoxide substrates |
Non-EH activity & non-epoxide substratesa |
|---|---|---|---|---|---|
| microsomal epoxide hydrolase (mEH) |
EPHX1 | 1970 | ER and plasma membrane |
epoxy-steroids; epoxy-fatty acids |
- |
| soluble epoxide hydrolase (sEH) |
EPHX2 | 1976 | cytosol and peroxisomes |
epoxy-fatty acids; hydroxy-epoxy- fatty acids |
Phosphatase: Terpenic pyrophosphates Lysophosphatidic acids |
| leukotriene A4 hydrolase (LTA4H) |
LTA4H | 1982 | cytosol | epoxy-fatty acids | Aminopeptidase: Opioid peptides N-arginine tripeptides |
| cholesterol epoxide hydrolase (ChEH) |
D8D7I, DHCR7… |
1984 | ER and plasma membrane |
5,6-epoxy- cholesterol |
- |
| hepoxilin epoxide hydrolase |
1989 | cytosol | hydroxy-epoxy- fatty acids |
- | |
| peg1/MEST | PEG1/MEST | 1995 | membrane- bound |
unknown | - |
| epoxide hydrolase 3 (EH3) | ABHD9 | 2009 | unknown | unknown | - |
| epoxide hydrolase 4 (EH4) | ABHD7 | 2009 | unknown | unknown | - |
a
Bifunctionnal enzymes are relatively rare in nature. Interestingly, both sEH and LTA4H have secondary enzymatic activities. The roles of these activities are not well known.