Figure 3. Perivascular leukocytic infiltrate and neointimal hyperplasia in allografts.
(A) PAS-staining of renal allografts depicts significant perivascular mononuclear cell infiltrates and extensive intrarenal arterial neointimal hyperplasia. (B) Masson Trichrome staining was performed on kidney representative image showing severe neointimal hyperplasia and luminal obliteration that is exclusively found in the allografts (upper panels). Elastin stain was performed (middle panels) to demonstrate the extent of neointimal hyperplasia. Higher-magnification images of the neointimal layer (vertical bar) in the respective groups (lower panels). (D) Quantification of neointimal hyperplasia as described in the methods. *P < 0.05. Horizontal bar = 100 μm.