Table 6.
Treatment-related organ weight differences when compared to controls (%)
| Necropsy | Day 11 (one-dose groups) | Day 85 (three-dose groups) | ||||||
|---|---|---|---|---|---|---|---|---|
| Sex | Male | Female | Male | Female | ||||
| Group | 2 | 3 | 2 | 3 | 5 | 6 | 5 | 6 |
| Treatment | MV1-F4 | Rouvax | MV1-F4 | Rouvax | MV1-F4 | Rouvax | MV1-F4 | Rouvax |
| Body weight (%) | +10 | −1 | −5 | −11 | +3 | −8 | −9 | +8 |
| Spleen | ||||||||
| Absolute (%) | +36 | +53 | +7 | −6 | +18 | +7 | +2 | +72 |
| Relative (%) | +23 | +45 | +14 | +6 | +13 | +16 | +12 | +60* |
| Cervical LN | ||||||||
| Absolute (%) | +52 | +16 | −21 | −40 | +81 | +146 | −2 | +7 |
| Relative (%) | +37 | +26 | −15 | −33 | +69 | +167 | +6 | −3 |
| Iliac LN | ||||||||
| Absolute (%) | −4 | +11 | −9 | +4 | +33 | +36 | −40 | +34 |
| Relative (%) | −9 | +20 | 0 | +17 | +30 | +47 | −34 | +24 |
| Thymus | ||||||||
| Absolute (%) | −20 | −26 | +19 | −7 | −8 | −42 | +4 | −24 |
| Relative (%) | −27 | −23 | +29 | +7 | −12 | −39 | +15 | −28 |
Results are differences (expressed as percentages) of the mean weight of three animals per vaccine group, as compared to those of control groups. Relative organ weight = organ weight/body weight
LN lymph nodes
*Statistically different (p < 0.05) from control groups (with significance based on values, not on percentages)