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. Author manuscript; available in PMC: 2013 May 10.
Published in final edited form as: Stat Med. 2012 Feb 23;31(10):915–930. doi: 10.1002/sim.4471

Table 1. Marginal Treatment Effect Analysis: Parameter estimates, sandwich standard errors, and bootstrap standard error.

Std: unaugmented GEE, Aug: augmented GEE. Ind: independence, Exch: exchangeable correlation with single parameter, Exch-TS: exchangeable with treatment-specific correlation parameters. SE1: unadjusted sandwich SE, SE2: sandwich with nuisance parameter adjustment, SE3: sandwich with small-sample adjustment, SE4: sandwich with small-sample and nuisance adjustments. Exch: Exchangeable correlation with single parameter, Exch-TS: Exchangeable with treatment-specific correlation parameters. ARE: square of the sandwich SE of the Std(Exch) estimator divided by the square of the sandwich SE of the indicated estimator. ARE boot: square of the bootstrap SE of the Std(Exch) estimator divided by the square of the bootstrap SE of the indicated estimator. ARE and Confidence intervals(CIs) are based on SE3 and SE4 for unaugmented and augmented estimators, respectively.

Estimate Sandwich Standard Error with Adjustments Bootstrap SE
β^1 SE1 SE2 SE3 SE4 95% CI ARE SE boot ARE boot
Std (Exch) 0.354 0.082 - 0.088 - (0.182,0.526) 1.000 0.081 1.000
Std (Exch-TS) 0.355 0.082 - 0.086 - (0.186,0.525) 1.034 0.085 0.910
Aug (Ind) 0.360 0.066 0.060 0.071 0.064 (0.236,0.485) 1.528 0.062 1.681
Aug (Exch) 0.364 0.063 0.057 0.067 0.060 (0.245,0.482) 1.730 0.064 1.582
Aug (Exch-TS) 0.360 0.063 0.061 0.066 0.064 (0.234,0.485) 1.769 0.082 0.966