Table 3.

Genes down regulated in the pediatric AML compared with normal control

	Gene	Description	NBM	AML	Fold Change	P
1	HOXB9	Homeobox B9	172. 9526	0. 6802	0. 004	<0. 0001
2	HOXA5	Homeobox A5	925. 5920	3. 4967	0. 004	<0. 0001
3	I D3	I nhi bi t or of DNA bi ndi ng 3	531. 6130	3. 0212	0. 006	<0. 0001
4	I GF2	Insulin-like growth factor 2	3. 4683	0. 0056	0. 002	<0. 0001
5	I D4	I nhi bi t or of DNA bi ndi ng 4	1422. 5193	0. 1906	0. 000	<0. 0001
6	FOXC1	Forkhead box C1	3676. 7938	26. 5854	0. 007	<0. 0001
7	HOXA7	Homeobox A7	15. 3933	0. 2396	0. 016	<0. 0001
8	CXCL1	Chemokine (C-X-C motif) ligand 1	0. 1130	0. 0022	0. 020	<0. 0001
9	HOXC9	Homeobox C9	138. 5471	4. 6762	0. 034	<0. 0001
10	HOXA3	Homeobox A3	16. 0470	0. 5843	0. 036	<0. 0001
11	HOXA4	Homeobox A4	263. 9704	7. 3403	0. 028	<0. 0001
12	DKK3	Dickkopf 3 homolog	8. 4810	0. 3344	0. 039	<0. 0001
13	JUN	Jun pr ot o- oncogene	1005. 8731	35. 1804	0. 035	<0. 0001
14	STAT4	Signal transducer and activator of transcription 4	11. 5854	0. 5332	0. 046	<0. 0001
15	HOXB1	Homeobox B1	23. 4942	0. 8037	0. 034	<0. 0001
16	FGFR1	Fibroblast growth factor receptor 1	3. 7172	0. 2184	0. 059	<0. 0001
17	FOXM1	For khead box M1	789. 1920	177. 9791	0. 226	0. 0008
18	HDAC2	Histone deacetylase 2	2925. 0236	618. 9588	0. 212	0. 0008
19	HMBS	Hydr oxymet hyl bi l ane synt hase	233. 0075	46. 3417	0. 199	0. 0008
20	I D1	I nhi bi t or of DNA bi ndi ng 1	140. 4811	14. 8120	0. 105	0. 0008
21	I D2	I nhi bi t or of DNA bi ndi ng 2	1221. 3259	360. 7765	0. 295	0. 001
22	CDKN2B	Cyclin-dependent kinase inhibitor 2B	23. 9879	5. 1419	0. 214	0. 001
23	DDX1	DEAD ( Asp- Gl u- Al a- Asp) box hel i case 1	2039. 8291	681. 2089	0. 334	0. 001
24	HDAC1	Histone deacetylase 1	1196. 1914	449. 9266	0. 376	0. 002
25	BRCA1	Br east cancer 1, ear l y onset	12. 8548	4. 4127	0. 343	0. 004

NBM: Mean value of the gene expression in NBM group AML: Mean value of the gene expression in pediatric AML group.