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Model for PKR binding to short and long dsRNAs. (A) Domain organization of PKR. (B) Two PKRs are able to bind to the 20 bp dsRNA at low salt via dsRBM1. PKR binds to dsRNAs of ≥ 30 bp with a larger site size via interaction of both dsRBM1 and dsRBM2. This binding model facilitates dimerization of the kinase domains, resulting in PKR activation.
