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. 2012 Nov 12;2:799. doi: 10.1038/srep00799

Figure 4. ER stress up-regulates the expression of inflammatory cytokines in adipose tissue of mice fed a high-fat diet.

Figure 4

Mice were fed a high-fat diet for 16 weeks and then treated with 4-PBA or TUDCA for 4 weeks at a dose of 1 g/kg/day. A, mRNA expression levels of ER stress markers in adipose tissue. mRNA expression levels of ER stress markers were significantly down-regulated by treatment with 4-PBA or TUDCA. Values are mean ± SD (n = 5). *p < 0.05 (unpaired Student's t-test). B, mRNA expression levels of inflammatory cytokines in adipose tissue. The expression levels of inflammatory cytokines were down-regulated by treatment with 4-PBA or TUDCA. Values are mean ± SD (n = 5). *p < 0.05 (unpaired Student's t-test).