Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Bar diagram showing SMAD7-promoter activity in H9c2-cardiocytes. Wild-type TIEG1 (WT) repressed SMAD7-expression. Four of the six variants as well as the control polymorphisms behave like WT with respect to TIEG1's effect on SMAD7 promoter activity, whereas the S225N-TIEG1 eliminates TIEG1's ability to repress SMAD7 promoter activity. Fold-change is the relative expression of the luciferase compared to empty vector control.
