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Bar diagram showing PTTG1-promoter activity in AKR2B-fibroblasts. Wild-type TIEG1 (WT) represses PTTG1-promoter, whereas 5 of 6 TIEG1-variants exhibited altered PTTG1 function significantly with regard to its promoter regulation. Fold-change is the relative expression of the luciferase compared to empty vector control.
