TABLE 1.
Characteristics of the Discovery Study Population*
| A. Hypertension Status of UVA Study Subjects (Mean ± SD) | ||
|---|---|---|
| Pre-study screen | Hypertensive Group |
Normotensive Group |
| Number of subjects | 55 | 130 |
| Male | 29 | 43 |
| Female | 26 | 87 |
| Age (yrs) | 52.4±12.3 | 45.0±13.9 |
| BMI | 25.8±2.9 | 24.1±2.9 |
| Systolic BP (mmHg) | 136±11.5 | 118.9±11.6 |
| Diastolic BP (mmHg) | 80.5±9.1 | 71.5±7.1 |
| MAP (mmHg) | 99.0±9.2 | 87.3±7.9 |
| B. Salt-Sensitivity Status of UVA Study Subjects (Mean ± SD): | |||
|---|---|---|---|
| Pre-study (Visit 1 or pre-study screen) |
Salt- Sensitive Subjects |
Salt - Resistant Subjects |
P value |
| Number of subjects | 34 | 151 | |
| Male | 10 | 62 | 0.208+ |
| Female | 24 | 89 | |
| Age (yrs) | 52.3 ± 13.9 | 46.0± 13.6 | 0.0156 |
| BMI | 25.4 ± 2.7 | 24.4 ± 3.0 | 0.0740 |
| After High Salt Diet | |||
| Systolic (mmHg) | 133.5 ± 11.6 | 120.1 ± 13.2 | <0.0001 |
| Diastolic (mmHg) | 79.4 ± 7.6 | 71.7 ± 8.9 | <0.0001 |
| MAP (mmHg) | 97.4 ± 7.5 | 87.8 ± 9.7 | <0.0001 |
| Heart Rate (Beats/min) | 65.8 ± 9.3 | 68.8 ± 11.1 | 0.1552 |
| Plasma Renin Activity (ng/mL/hr) | 0.39± 0.20 | 0.58 ± 0.49 | 0.0352 |
| Plasma Aldosterone (ng/dL) | 4.02 ± 2.85 | 3.65 ± 3.29 | 0.5520 |
| Urinary Sodium Excretion (mmol/24 hrs) | 226.3 ± 37.8 | 218.8 ± 57.3 | 0.5186 |
| Total Urine Creatinine (g/24hrs) | 1.31 ± 0.4 | 1.31 ±0.4 | 0.4576 |
| After Low Salt Diet | |||
| Systolic (mmHg) | 118.6 ± 11.5 | 119.2 ± 15.4 | 0.8510 |
| Diastolic (mmHg) | 70.3 ± 5.2 | 74.1 ± 9.0 | 0.0192 |
| MAP (mmHg) | 86.4 ± 6.4 | 89.1 ±9.5 | 0.1078 |
| Heart Rate (Beats/min) | 72.5 ±9.0 | 74.1 ±10.9 | 0.4100 |
| Plasma Renin Activity (ng/mL/hr) | 4.5 ± 3.4 | 6.1 ± 3.7 | 0.0303 |
| Plasma Aldosterone (ng/dL) | 27.9 ± 12.8 | 34.1 ± 19.8 | 0.0830 |
| Urinary Sodium Excretion (mmol/24 hrs) | 18.6 ±6.2 | 17.4 ±7.4 | 0.3076 |
| Total Urine Creatinine (g/24 hrs) | 1.3 ±0.3 | 1.3 ± 0.4 | 0.6872 |
| C. Distribution of Salt-Sensitivity Status between UVA Hypertensive and Normotensive Study Subjects | |||
|---|---|---|---|
| BP Status | SS (Case) | SR (Control) | Total |
| HTN | 17(50%, 30.9%) | 38(25.2%, 69.1%) | 55 |
| NTN | 17(50%, 13.1%) | 113(74.8%, 86.9%) | 130 |
| Total | 34 | 151 | 185 (100%) |
*
If continuous variables were normally distributed, a t-test was used to compare the two groups. If not normally distributed, a Wilcoxon-Rank Sum was used to compare the two groups. The non-normal variables were age, MAP (low salt), systolic (low salt), and diastolic (high and low salt). Also, note that BP measurements were uniformly higher in the hypertensive vs. normotensive group (all P<0.0001).
+
Comparison of distribution of gender in SS vs. SR subjects