TABLE 2.

Associations of Candidate Gene SNPs with Salt-Sensitivity and Blood Pressure

Gene Name	Gene Desig- nation	SNP Designation	rs Number	SS Status vs Genotype P value*	HTN Status vs Genotype P value*
Aldosterone synthase	CYP11B2	C-344T, 5' near gene	rs1799998	0.8504	0.331
Alpha Adducin 1	ADD1	G460W	rs4961	0.443+	0.027+
Alpha Adducin 2	ADD2	Intron 2	rs1541582	0.194+	0.897+
Angiotensinogen	AGT	M268T	rs699	0.326	0.885
Angiotensin II Receptor, Type I	AGTR1	A1166C, 3' UTR	rs5186	0.936+	0.135
Angiotensin Converting Enzyme	ACE	Intron 15	rs1799752	0.610	0.228
Caveolin 1	CAV1	Intron 2	rs3807990	0.576	0.767+
		Intron 2	rs3840634	0.813+	0.271+
Cholecystokinin A Receptor	CCKAR	H210Y	rs41267457	NA	NA
Cholecystokinin B Receptor	CCKBR	L37F	rs1805000	NA	NA
		V125I	rs1805002	0.247+	0.908
Cytochrome P450-4A11	CYP4A11	F434S	rs1126742	0.623+	0.334+
Dopamine Receptor D2	DRD2	−141C, 5' near gene	rs1799732	0.574+	0.374+
		E713K	rs1800497	0.721+	0.603+
		Intron 1	rs1079597	0.721+	0.302+
		3' UTR	rs6276	0.0742	0.584+
G Protein-coupled Receptor Kinase 4	GRK4	R65L	rs2960306	0.020	0.227
		A142V	rs1024323	0.389	0.500
		A486V	rs1801058	0.846	0.018
Nitric Oxide Synthase 3 (endothelial cell)	eNOS	E298D	rs1799983	0.170	0.376
Protein Phosphatase 2, Regulatory Subunit B, Gamma Isoform	PPP2R2C	T146T	rs35368770	NA	NA
		T204T	rs35410672	NA	NA
		I429I	rs3796403	0.892	0.281
		A431A	rs11545013	NA	NA
Sodium Bicarbonate Cotransporter, Member 5	SLC4A5	Intron 17	rs7571842	<0.001+	0.825
		Intron 20	rs10177833	<0.001+	0.849
Sorting Nexin 1	SNX1	E33R, frameshift	rs34910981	NA	NA
		P211S	rs1130604	NA	NA
		D466N	rs1802376	NA	NA
Sorting Nexin 5	SNX5	P92L	rs6045116	NA	NA
Sorting Nexin 19	SNX19	V361L	rs3751037	0.198+	0.231+
		S407G	rs3190345	0.319	0.434+
		L618F	rs681982	NA	NA
		N753S	rs4414223	0.230+	0.185+
		L878R	rs2298566	0.361	0.320+

^*P values based on 2 × 3 Chi square analyses unless otherwise noted.

⁺Based on pooling rare homozygotes with heterozygotes due to there being too few homozygotes.

NA – Not analyzed because minor allele frequency is too low