. Author manuscript; available in PMC: 2013 Oct 11.

Published in final edited form as: J Med Chem. 2012 Sep 19;55(19):8283–8302. doi: 10.1021/jm300472k

Table 2.

The relative binding thermodynamic values of 8b relative to 8a, and 8d relative to 8c as determined by ITC

	ΔΔG_Kd (kJ/mol)	ΔΔH (kJ/mol)	−TΔΔS (kJ/mol)
8b–8a	−5.6	−13.3	7.7
8d–8c	−2.2	2.5	−4.7