Table 4.
Riboflavin production by insertion and knockout mutants of Pichia guilliermondii
| Strains of P. guilliermondii | Conditions of growth
|
|||
|---|---|---|---|---|
| 3.6 μM of iron
|
0.18 μM of iron
|
|||
| Growth (mg dry cells weight mL−1) | Riboflavin productivity (μg mg−1 dry cells weight) | Growth (mg dry cells weight mL−1) | Riboflavin productivity (μg mg−1 dry cells weight) | |
| R-66 | 6.0 | 0.11 | 4.0 | 4.45 |
| IS12 | 4.2 | 0.25 | 1.5 | 6.8 |
| Δvma1–17 | 1.5 | 0.50 | No growth | – |
| IS19 | 5.9 | 0.35 | 2.5 | 8.0 |
| Δfes1–77 | 2.0 | 0.15 | 1.3 | 3.6 |
| IS45 | 5.2 | 0.7 | 4.0 | 11.2 |
| Δfra1–45 | 5.4 | 0.72 | 4.3 | 11.7 |