Table 1.

Variables and measurement instruments

Endpoint	Measuring instrument	Sources	Baseline	Year 1	Year 2	Year 3
Cardiovascular events	eCRF completed with the CCR	General practitioners	✓	✓	✓	✓
Mortality and cause of death	Death certificate Family reported	General practitioners, National Death Index Interview by psychologist	✓	✓	✓	✓
Major depressive disorder	MINI	Interview by psychologist		✓	✓	✓
Generalized anxiety disorder	MINI	Interview by psychologist		✓	✓	✓
Sociodemographic variables	Self-report questionnaire	Interview by psychologist	✓
Personal health habits	Self-report	Interview by psychologist	✓	✓	✓	✓
Anthropometric variables	eCRF completed with the CCR	General practitioners	✓	✓	✓	✓
Comorbidity and complications	eCRF completed with the CCR	General practitioners	✓	✓	✓	✓
Laboratory results	eCRF completed with the CCR	General practitioners	✓	✓	✓	✓
Treatment	eCRF completed with the CCR	General practitioners	✓	✓	✓	✓
Sleep quantity	Self-report	Interview by psychologist	✓	✓	✓	✓
Sleep quality	AIS	Interview by psychologist	✓	✓	✓	✓
Personal and family history of psychiatric disorder	Self-report	Interview by psychologist	✓
	CCR	General practitioners
Social support	First item of RSE	Interview by psychologist		✓	✓	✓
HRQoL	SF-12	Interview by psychologist		✓	✓	✓

eCRF: electronic case report forms; CCR: computerized clinical records; MINI: Mini-International Neuropsychiatric Interview; AIS: Athens Insomnia Scale ; SF-12: Short-Form Health Survey.