Table 4.
Characteristics of gene sets in publications where whole microarray data were unavailable
| Study | Number and distribution of samples | Gene list |
|---|---|---|
| Asgharzadeh et al., 2006 [35] |
102 NB |
55 gene model for the prediction of high molecular risk NB |
| Berwanger et al., 2002 [36] |
Stage 1: 19, stage 4: 21 NB |
36 genes differently expressed between stage 1 and stage 4 NB |
| Fischer et al., 2010 [40] |
81 unfavorable, 8 favorable NB, without 11q aberration |
163 genes differently expressed between favorable and unfavorable NB |
| Oberthuer et al., 2006 [42] |
251 NB, among these 77 was used to construction of a gene expression–based classifier and 177 to validate it |
60 genes with higher than 2-fold expression changes from 144 gene predictor of favorable and unfavorable NB |
| Oberthuer et al., 2007 [33] |
79 favorable and 48 unfavorable NB |
5 genes with higher than 2-fold expression changes from 349 gene predictor of favorable and unfavorable NB |
| Ohira et al., 2005 [34] |
136 NB |
41 top-ranked genes used for prediction of 2 year and 5 year prognosis of NB |
| Schramm et al., 2005 [31] |
59 MYCN-non-amplified, 9 MYCN-amplified NB |
28 top-ranked genes to discriminate MYCN-non-amplified and MYCN-amplified NB |
| |
Stage 1: 20, stage 2: 16, stage 3:7, stage 4: 15, stage 4S: 10 NB |
30 top-ranked genes to discriminate stage 1–2 and stage 3–4 NB |
| |
|
22 top-ranked genes to discriminate stage 4S and stage 4 NB |
| Takita et al., 2004 [43] |
stage 1: 9, stage 2: 4, stage 4: 6, stage 4S: 1 NB |
60 top-ranked genes to discriminate stage 1–2 and stage 4 NB |
| Thorell et al., 2009 [44] |
16 favorable and 15 unfavorable NB |
81 genes differently expressed between favorable and unfavorable NB, validated by QRT-PCR |
| Vermeulen et al., 2009 [45] |
579 NB |
59 prognostic genes for high risk NB |
| Brown et al., 2008 [37] |
12 MEN2A, 11 VHL PCC |
17 genes differently expressed between MEN2A and VHL by SAM (fold change: 2-fold, delta lower than 0.05) |
| Eisenhofer et al., 2004 [38] |
7 MEN2A, 12 VHL PCC |
493 genes differently expressed between MEN2A and VHL PCC |
| Eisenhofer et al., 2008 [39] |
32 MEN2A, 47 VHL PCC |
42 selected pathway components differently expressed between MEN2A and VHL PCC |
| Huynh et al., 2006 [41] |
13 MEN2A, 18 VHL PCC |
15 genes selected differently expressed genes between MEN2A and VHL PCC |
| López-Jiménez et al., 2010 [32] | 8 SDHB, 1 SDHC, 4 SDHD, 15 VHL, 17 RET, 4 NF1 | 444 genes differently expressed between VHL/SDH and RET/NF1 PCC |