Figure 2.

Neither cisplatin nor paclitaxel induces acute mechanical and cold hypersensitivity. Mice were intraperitoneally administered vehicle, cisplatin (5 mg/kg; A, B), or paclitaxel (6 mg/kg; C, D), and 2 h later the 50% withdrawal threshold to mechanical stimulation ( A, C) and the escape behaviors in response to cold stimulation ( B, D) were evaluated. Data are presented as the means ± S.E.M. of 6 mice.